George N. Chaldakov
Bulgaria
Research Article
Serum BDNF and NGF Modulation by Olive Polyphenols in Alcoholics during Withdrawal
Author(s): Mauro Ceccanti, Valentina Carito, Mario Vitali, Silvia Iannuzzi, Luigi Tarani, Sara De Nicolo’, Marco Ceccanti, Stefania Ciafre’, Paola Tirassa, Ida Capriglione, Giovanna Coriale, Angela Iannitelli, George N. Chaldakov and Marco FioreMauro Ceccanti, Valentina Carito, Mario Vitali, Silvia Iannuzzi, Luigi Tarani, Sara De Nicolo’, Marco Ceccanti, Stefania Ciafre’, Paola Tirassa, Ida Capriglione, Giovanna Coriale, Angela Iannitelli, George N. Chaldakov and Marco Fiore
Many studies have suggested possible relationships between the neurotrophins brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) and alcohol addiction. Previous reports demonstrated severe changes in these neurotrophins in the serum of alcohol dependent patients and during withdrawal. Alcohol dependence syndromes during consumption and/or withdrawal are also characterized by elevated oxidative stress. Polyphenols, including olive polyphenols, are natural compounds known to possess marked antioxidant properties. Thus, this study was carried out in order to verify the effects of a blend of olive polyphenols supplementation containing mostly hydroxytyrosol (50 mg/day for 15 consecutive days) in alcoholic men during withdrawal on serum .. View More»
