Helga Engi
Hungary
Research Article
The Role of Stroma in Tumour-Host Co-Existence: Some Perspectives in Stroma-Targeted Therapy of Cancer
Author(s): Joseph Molnár, Ilona Mucsi, Helga Engi, Gabriela Spengler, Leonard Amaral, Attila Zalatnai, Qi Wang and Ben Efraim ShlomoJoseph Molnár, Ilona Mucsi, Helga Engi, Gabriela Spengler, Leonard Amaral, Attila Zalatnai, Qi Wang and Ben Efraim Shlomo
Cancer grows at the expense of the host as a parasite or superparasite following the second law of thermodynamics (conservation of energy). When the cancer cell progresses via replication to the special state called “spheroid”, a new phase begins with its intimiate interaction and development of responses from the stroma which together assist in the formation of a full blown cancer. Among the processes involved are the development of blood vessels and lymphatic channels which are essential for maintenance and further growth of the cancer mass. In this way the condition of “parasitism” is completed with simultaneous suppression of the immune response of the host to the histoincompatability of the tumor mass. Stroma/parenchyma promotes cancer invasion by feeding cancer cells and inducing immune tolerance. The dynamic changes in composition of stroma and biologica.. View More»
