Hiba Asrar K
Dental institute, King's College London,
England
United Kingdom
Review Article
Ips Progression a Decade Devoted
Author(s): Hiba Asrar KHiba Asrar K
Yamanaka and Takahashi’s astonishing discovery in 2006 revolutionized the world of stem cells. Simplicity and reproducibility of IPSC’s cells opened doors for extensive therapeutic advancements and potential clinical trials particularly in the field of Regenerative medicine. In 2012, nobel prize was presented to both researchers for the breakthrough in reprogramming somatic cells to a pluripotent state with the expression of “Yamanakas cocktail” of OKSM quartet transcription factors: sex determining region y box2 (sox2), octamer binding transcription factor4 (oct4), krupple like factor (klf4) and myelocymatosis oncogene (c-myc). Rationale of iPS use is attributed to its unlimited cell source circumventing ethical hindrance. This comprehensive review will summarize mechanisms of IPS production and cell therapy applications. Moreover, appreciate the improvements .. View More»
