Hongbo Chi
Department of Immunology, St. Jude Children’s Research Hospital,
Memphis, TN 38105
Tanzania
Special Issue Article
Metabolic Control of Th17 Cell Generation and CNS Inflammation
Author(s): Kai Yang and Hongbo ChiKai Yang and Hongbo Chi
Multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system (CNS), results from
uncontrolled auto reactive T cells that infiltrate the CNS and attack the myelin sheath. Th17 cells play a prominent role
in the pathogenesis of MS and experimental autoimmune encephalomyelitis (EAE), a mouse model of MS. Extensive
studies have focused on understanding the roles of cytokine signaling and transcriptional network in the differentiation
of Th17 cells and their pathogenicity in CNS inflammation. Aside from these events, activated T cells dynamically
reprogram their metabolic pathways to fulfill the bioenergic and biosynthetic requirements for proper T cell functions.
Emerging evidence indicates that modulation of these metabolic pathways impinges upon the differentiation of
Th17 cells and the pathogenesis of EAE... View More»
