Howard A Crystal
Tanzania
Research Article
Ghrelin, Amylin, Gastric Inhibitory Peptide and Cognition in Middle-Aged
HIV-Infected and Uninfected Women: The Women's Interagency HIV Study
Author(s): Samy I McFarlane, Michelle M Mielke, Anthony Uglialoro, Sheila M Keating, Susan Holman, Howard Minkoff, Howard A Crystal and Deborah R GustafsonSamy I McFarlane, Michelle M Mielke, Anthony Uglialoro, Sheila M Keating, Susan Holman, Howard Minkoff, Howard A Crystal and Deborah R Gustafson
Objective: To explore the gut-brain axis by examining gut hormone levels and cognitive test scores in women with (HIV+) and without (HIV-) HIV infection.
Design/methods: Participants included 356 women (248 HIV+, 108 at risk HIV-) in the Brooklyn Women’s Interagency HIV Study (WIHS) with measured levels of ghrelin, amylin and gastric inhibitory peptide (GIP), also known as glucose-dependent insulinotropic polypeptide. Cross-sectional analyses using linear regression models estimated the relationship between gut hormones and Trails A, Trails B, Stroop interference time, Stroop word recall, Stroop color naming and reading, and Symbol Digit Modalities Test (SDMT) with consideration for age, HIV infection status, Wide Range Achievement Test score (WRAT), CD4 count, insulin resistance, drug use, and race/ethnicity.. View More»
