Hugo Maia Jr
Centro de Pesquisas e Assistênciaem Reprodução Humana (CEPARH),
Brazil
Research Article
The Effect of Oral Contraceptives Combined With Pycnogenol (Pinus Pinaster) On Aromatase and VEGF Expression in the Eutopic Endometrium of Endometriosis Patients
Author(s): Hugo Maia Jr, Clarice Haddad, Nathaniel Pinheiro and Julio CasoyHugo Maia Jr, Clarice Haddad, Nathaniel Pinheiro and Julio Casoy
Oral contraceptives are effective in curbing down endometrial inflammation and decreasing endometriosisrelated dysmenorrhea. This antiinflammatory action is mediated by the progestin component of the pill and it involves the blockade of the NF-kappa.B inflammatory cascade. One of the genes activated by NF-kappa.B is the one that codes for angiogenic factors such as VEGF. In this respect, oral contraceptives would be expected to block VEGF expression in the endometrium. However, the use of oral contraceptives alone failed to significantly decrease the percentage of endometria testing positive for VEGF. Introducing pycnogenol to the treatment regimen, on the other hand, significantly reduced the percentage of VEGF-positive cases in oral contraceptive users. Since pycnogenol blocks NF-kappa.B gene transcription after its binding to DNA, the combination of oral contraceptives with pycnoge.. View More»
