Ian Neville Johnston
Australia
Research Article
Neuroimmunological Manifestations of Chemotherapy Exposure: Implications for Mucositis, Glia and Cognition
Author(s): Juliana Esma Bajic, Gordon Stanley Howarth, Ian Neville Johnston and Mark Rowland HutchinsonJuliana Esma Bajic, Gordon Stanley Howarth, Ian Neville Johnston and Mark Rowland Hutchinson
Chemotherapy drugs reduce quality of life often causing acute and delayed central side-effects, termed chemotherapy-induced cognitive impairment (CICI). Another dose-limiting chemotherapy-induced side-effect is oral and intestinal mucositis which results in significant gastrointestinal (GIT) damage and intestinal inflammation. Recent interest has been paid to neurological complications arising in patients with gut disorders, yet little attention has been paid to the role GIT damage plays in CICI. Our current understanding of neuronal adaptations and behavioral consequences resulting from immune system dysregulation has paved the way for investigation into the neuroimmunological manifestations associated with chemotherapy. In a clinical setting cancer patients experience a cluster of symptoms, similar to that manifested in cytokine-induced sickness responses. Accordingly, it is suggest.. View More»
