Ileana Constantinescu
Bucharest
Romania
Research Article
MicroRNAs Expression Profiles in Romanian Patients with Urinary Bladder Cancer-Preliminary Results
Author(s): Maria Mirela Iacob, Costin Petcu, Tatiana Vassu-Dimov and Ileana ConstantinescuMaria Mirela Iacob, Costin Petcu, Tatiana Vassu-Dimov and Ileana Constantinescu
Aim: Bladder cancer is known to be the ninth most common cancer worldwide. Current diagnostic and prognostic tools are insufficient to predict clinical outcome and response to personalized therapy. Carcinogenesis mechanisms involve genetic and epigenetic pathways. The aim of this research was to develop optimal experimental condition to assess the expression of selected miR-145-3p, miR-145-5p, miR-152 and miR-182 in patients with urinary bladder tumors, in order to correlate this with the tumor clinic routine characteristics. This approach would add more information on the etiology of bladder cancer tumors in an attempt to elaborate molecular algorithm.
Methods: This work approaches epigenetic modifications in order to investigate the dynamics of certain tissue extracted microRNA specie.. View More»
