Journal of Multiple Sclerosis
ISSN - 2376-0389NLM - 101654564
Ilias Doxiadis
England
Research Article
HLA-DRB1* Allele Frequencies in Pediatric, Adolescent and Adult-Onset Multiple Sclerosis Patients, in a Hellenic Sample. Evidence for New and Established Associations
Author(s): Maria C Anagnostouli, Argyro Manouseli, Artemios K Artemiadis, Serafeim Katsavos, Constantina Fillipopoulou, Sotirios Youroukos, Spyros Efthimiopoulos and Ilias DoxiadisMaria C Anagnostouli, Argyro Manouseli, Artemios K Artemiadis, Serafeim Katsavos, Constantina Fillipopoulou, Sotirios Youroukos, Spyros Efthimiopoulos and Ilias Doxiadis
Studies in many populations consistently have showed that the human leukocyte antigens (HLA) and especially the DRB1*15 allele has by far the strongest genetic association with multiple sclerosis (MS). The aim of this study was to investigate the role of HLA-DRB1* alleles in MS risk/resistance and onset. A sample of 165 Hellenic MS patients (18 with pediatric-, 24 with adolescent- and 123 with adult-onset MS) and 107 healthy volunteers were examined with molecular techniques. Comparisons were made according to the Benjamini-Yekutieli method for p value correction. Both adult-onset MS patients and early-onset MS patients (age at onset below 20 years-old) had a significantly higher frequency of the DRB1*15 allele and a significantly lower frequency of the DRB1*11 allele compared to controls. For the early-onset vs. healthy group comparison, su.. View More»
