Jacob Z Dalgaard
Coventry, Farmer Ward Road Kenilworth, Warwickshire CV82DJ
Opinion Article
Could Multiple Sclerosis Develop due to Epstein Barr Virus Infections Causing a Time-Delayed Transcriptional-Activation of Human Endogenous Retroviruses?
Author(s): Jacob Z DalgaardJacob Z Dalgaard
The underlying cause of multiple sclerosis (MS) is not fully understood. However, it is known that Epstein Barr virus (EBV) infections pre-date the development of the disease. Here I explore whether the underlying cause of Multiple Sclerosis can be explained by an inappropriate intra-cellular transcriptional response to the integration of the EBV in the genome of neural cells. Such a re-programming is proposed to lead to the transcriptional activation of other dormant viruses, human endogenous retroviruses (HERVs), followed by the “auto-immune” response and inflammation observed in the brain of MS patients?
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