James W Geddes
Spinal Cord and Brain Injury Research Center, B477 Biomedical & Biological Sciences Research Building (BBSRB) 741. S. Limestone Street,
Lexington, KY 40536-0509
Tanzania
Research Article
Extent of Cerebrovascular Disruption Following Blast Exposure is Influenced by the Duration of the Positive Phase in Addition to Peak Overpressure
Author(s): Dexter V Reneer, Carolyn A Crowdus, Sarbani Ghoshal, Julie Corkins, Richard D Hisel, Braden T Lusk and James W GeddesDexter V Reneer, Carolyn A Crowdus, Sarbani Ghoshal, Julie Corkins, Richard D Hisel, Braden T Lusk and James W Geddes
Blast-induced traumatic brain injury (bTBI) has been described as the defining injury of Operations Enduring
Freedom and Iraqi Freedom (OEF/OIF). Although there has been a significant amount of research characterizing
the brain injury produced by blast, greater understanding of the contribution of each component of the shockwave
to the injury is needed. Large animal models of bTBI utilize chemical explosives as their shockwave source while
small animal models predominantly utilize compressed air-driven membrane rupture as their shockwave source. We
previously designed and built a multi-mode shock tube capable of utilizing air-driven membrane rupture or chemical
explosives (oxyhydrogen: A 2:1 mixture of hydrogen and oxygen gasses to produce a shockwave. Compressed airdriven
shockwaves exhibited longer duration positive phases than compre.. View More»
