Jan Jacques Michiels
Goodheart Institute, Bloodcoagulation and Vascular Medicine Center,
Erasmus Tower, Veenmos 13, 3069 AT Rotterdam
England
Research Article
Erythromelalgic Thrombotic Thrombocythemia (ETT) and Hemorrhagic Trombocythemia (HT) in Patients with Essential Thrombocythaemia (ET) and Polycythaemia Vera (PV)
Author(s): Jan Jacques MichielsJan Jacques Michiels
We analysed between 1908 and 1985 of two hundred cases of thrombocythemia from the literature between 1908 and 1985. Erythromelalgic, acrocyanotic ischemia and digital gangrene, cerebral or coronary ischemic events (erythromelalgic thrombotic thrombocyhemia: ETT) in 99 thrombocythemia patients (essential thrombocythemia: ET N=67 and polycythemia vera: PV N=32) occured at platelet counts in excess of 400 × 109 /L. Hemorrhagic complications at time of presentation of hemorrhagic thrombocythemia (HT) in 100 HT patients included melana and/or hematemesis, skin bleedings (bruises, subcutaneous hematomas, painfull hematomas after trauma, ecchymoses, but not petechiae, epistaxis and gum bleeding and secondary bleeding after trauma or surgery. ETT occurred at an early stage of thrombocythemia with a mean platelet count of 1110+477 × 109 /L, whereas HT occurred at significantly hig.. View More»
