Jian Su
IR Iran
Research Article
Diallyl Disulfide Increases Histone Acetylation and P21WAF1 Expression in Human Gastric Cancer Cells In vivo and In vitro
Author(s): Bo Su, Shu Lin Xiang, Jian Su, Hai Ling Tang, Qiang Jin Liao, Yu Juan Zhou and Su QiBo Su, Shu Lin Xiang, Jian Su, Hai Ling Tang, Qiang Jin Liao, Yu Juan Zhou and Su Qi
Diallyl disulfide (DADS) exerts numerous anticancer effects, involving multiple molecular mechanisms. In particular, DADS has been revealed as a potential inhibitor attenuating histone deacetylase (HDAC) activity, which could aid cancer prevention and therapy by inducing histone hyperacetylation and consequently reactivating epigenetically silenced tumor suppressor genes involved in cancer initiation and progression. In an in vitro study, we demonstrated that DADS increased histones H3 and H4 acetylation in human gastric cancer MGC803 cells in a time-dependent fashion, accompanied by increased p21WAF1 protein levels, which was consistent with G2/M phase cell cycle arrest. DADS
also demonstrated dose-dependent antitumor effects in MGC803-xenografted nude mice in vivo, resulting in tumor cells growth inhibition and G2/M phase arrest. Acetylated histones H3 and H4 were up-regulate.. View More»
