Juan Sanchis
Spain
Research Article
Insulin Resistance and Short-Term Mortality in Patients with Acute Myocardial Infarction
Author(s): Rafael Sanjuan, Maria L Blasco, Arturo Carratala, Alfonso Mesejo, Julio Nunyez, Vicente Bodi and Juan SanchisRafael Sanjuan, Maria L Blasco, Arturo Carratala, Alfonso Mesejo, Julio Nunyez, Vicente Bodi and Juan Sanchis
Background: Homeostasis Model Assessment (HOMA) is a widely used index to study the role of insulin resistance (IR).Our objective has been to clarify if IR would predict short-term mortality in patients with acute myocardial infarction (AMI).
Methods: Observational prospective study in 518 consecutive patients with a clinical diagnosis of AMI with or without diabetes mellitus. We evaluated glucose and insulin levels at baseline in order to estimate IR and mortality. Association between IR and mortality was assessed by means of the Cox regression analysis, and discriminative accuracy of the multivariate model with the Harrell’s C statistic.
Results: In-hospital mortality was 6% (32/518 of patients). Using ROC curve, in non-diabetic patients, IR index >2.2 was the best cut-off for predicting in-hospital mortalit.. View More»
