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Journal of Arthritis

ISSN - 2167-7921

Kate Lygrissea

Kate Lygrissea

Tanzania

Publications
  • Review Article
    Role of MicroRNA in Osteoarthritis
    Author(s): Mingcai Zhang, Kate Lygrissea and Jinxi WangaMingcai Zhang, Kate Lygrissea and Jinxi Wanga

    Although the potential effect of aberrant expression of catabolic and anabolic genes on the development of osteoarthritis (OA) is well-documented, the regulatory mechanism for the expression of these genes in articular chondrocytes remains to be elucidated. The recent advances in epigenetic studies have identified microRNA (miRNA) as one of the epigenetic mechanisms for the regulation of gene expression. This mini review highlights the role of miRNA in the regulation of gene expression in articular chondrocytes and its significance in the pathogenesis of OA, with a discussion on the potential of miRNA as a new biomarker and therapeutic target for OA. Further investigations are required to determine the specificity, sensitivity, and efficacy of miRNA for clinical applications .. View More»

    DOI: 10.4172/2167-7921.1000239

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