Kazim Senel
Turkey
Research Article
Efficacy and Safety of Natural Eggshell Membrane (NEM®) in Patients with Grade 2/3 Knee Osteoarthritis: A Multi-Center, Randomized, Doubleblind, Placebo-Controlled, Single-crossover Clinical Study
Author(s): Nurten Eskiyurt, Merih Saridoğan, Kazim Senel, Rezzan Günaydin, Akin Erdal, Elif Özyiğit, ÜlKü Akarırmak, Ömer Faruk Şendur, Kayra Barut, Gülseren Akyüz, Tuğba Özsoy, Tiraje Tuncer, Özlem Karataş, Jale İrdesel, Ayşegül Ketenci and Cem AydoganNurten Eskiyurt, Merih Saridoğan, Kazim Senel, Rezzan Günaydin, Akin Erdal, Elif Özyiğit, ÜlKü Akarırmak, Ömer Faruk Şendur, Kayra Barut, Gülseren Akyüz, Tuğba Özsoy, Tiraje Tuncer, Özlem Karataş, Jale İrdesel, Ayşegül Ketenci and Cem Aydogan
Objective: To evaluate the efficacy and safety of NEM® (natural eggshell membrane), in patients with grades 2 and 3 knee osteoarthritis (OA) having significant joint pain and stiffness, in a large, multi-center clinical trial.
Subjects and methods: This study was a randomized, double-blind, placebo-controlled, multi-center, single-crossover design. One-hundred sixty subjects (male, 32; females, 134; age ≥ 40 years) with grade 2 or 3 knee OA for 1-5 years were randomized to either NEM (n=83) 500 mg once daily or placebo (n=83) for 30 days. Osteoarthritis was evaluated using the Western Ontario and McMaster Universities OA index. NEM and placebo groups were compared at baseline, day 7, and day 30. After 30 days on placebo, the placebo group crossed over while remaining blinded and was provided with NEM (500 mg) for an additional 60 days.. View More»
