Kevin T McVary
Tanzania
Research Article
Nitric Oxide Synthase is Necessary for Normal Urogenital Development
Author(s): Christopher Bond, Omer Onur Cakir, Kevin T McVary and Carol A PodlasekChristopher Bond, Omer Onur Cakir, Kevin T McVary and Carol A Podlasek
Introduction: Neuronal nitric oxide synthase (NOS-I) is significantly decreased with Cavernous Nerve (CN) injury in Erectile Dysfunction (ED) models. Increased apoptosis and collagen deposition accompany decreased NOS/CN injury, however these changes are typically attributed to the altered signaling of other factors, and a contribution of NOS in maintenance of urogenital structures has not previously been examined. Morphological changes in the corpora cavernosa occur at the same time as decreased NOS, suggesting a potential connection between decreased/inhibited NOS and morphological changes associated with ED. In this study we propose that NOS impacts urogenital morphology during development and will examine this hypothesis by NOS inhibition with L-NAME.
Methods: Primary outcomes were H&E, western and TUNEL to determine if penis, prostate and bladder morphology were alt.. View More»
