Kiran Dahiya
India
Research Article
Comparative Evaluation of Palliative Radiotherapy with Chemotherapy vs.
Palliative Radiotherapy Alone in Locally Advanced Head and Neck Cancer
Author(s): Manas Dubey, Rakesh Dhankhar, Vivek Kaushal, Kiran Dahiya, Om Parkash, Anil Kumar Dhull and Rajeev AtriManas Dubey, Rakesh Dhankhar, Vivek Kaushal, Kiran Dahiya, Om Parkash, Anil Kumar Dhull and Rajeev Atri
Background: The aim of the study was to evaluate and compare the efficacy, tolerability and toxicity of two palliative radiotherapy (RT) schedules in locally advanced head and neck carcinoma (LAHNC), i.e., Quad Shot schedule with chemotherapy and Quad Shot schedule alone.
Methods: The patients were randomly divided into two groups of 30 each. Group I patients were planned for 14.8 Gy in 4 fractions over 2 days every 3 weeks for three cycles. All these patients also received paclitaxel 60 mg/m2 intravenous. Group II patients received 14.8 Gy in 4 fractions over 2 days every 3 weeks for three cycles alone. All these patients in Group I and II received total radiation dose of 44.4 Gy.
Results: At the end of treatment, complete tumor response (CR) in Group I was better than Group II (40% vs. 36.7%). Disease .. View More»
