Journal of Multiple Sclerosis
ISSN - 2376-0389NLM - 101654564
Laura Ghezzi
Italy
Research Article
Neurophysiological Profile, Walking Performance Tests and Self-Reported Questionnaires in Spastic Patients with MS: A Pilot Study
Author(s): Alberto Calvi, Milena De Riz, Anna Pietroboni, Laura Ghezzi, Andrea Arighi, Giorgio Fumagalli, Paola Basilico, Marta Scarioni, Maurizio Vergari, Martina Nigro, Emanuela Oldoni, Chiara Fenoglio, Daniela Galimberti, Elio Scarpini and Alberto PrioriAlberto Calvi, Milena De Riz, Anna Pietroboni, Laura Ghezzi, Andrea Arighi, Giorgio Fumagalli, Paola Basilico, Marta Scarioni, Maurizio Vergari, Martina Nigro, Emanuela Oldoni, Chiara Fenoglio, Daniela Galimberti, Elio Scarpini and Alberto Priori
Nabiximols is currently being used as an add-on therapeutic option to treat severe forms of multiple sclerosis (MS) spasticity, especially in the progressive phase of the disease.
The aim of this exploratory study is to evaluate the response to Nabiximols therapy and modifications in neurophysiological profile, improvement in walking performance tests and self-reported questionnaires, as possible further outcome measures of spasticity.
8 MS patients were recruited to start Nabiximols therapy, all responders in terms of significant reduction of numerical rating scale (NRS). The patients underwent measurements of lower limbs H-reflex and F wave before treatment (baseline) and after 4 and 8 weeks (T1 and T2) of treatment with Nabiximols titrated to optimal dosage, along with timed 25-foot walk test (T25FW), six-minute walk test (6MWT) and questionnaires evaluating subject.. View More»
