Leong KN
Malaysia
Research Article
Outcome of Isoniazid Preventive Therapy in Adults Living with HIV in Penang, Malaysia
Author(s): Lim CL, Wong PS, Pereirasamy L, Ang PP, Leong KN and Chow TSLim CL, Wong PS, Pereirasamy L, Ang PP, Leong KN and Chow TS
Isoniazid preventive therapy (IPT) is a recommended strategy by World Health Organization (WHO) for prevention of active TB infection in people living with HIV. However, data on feasibility and outcome of IPT in Asia are limited. We conducted a retrospective study of 242 HIV patients in Penang who were commenced on IPT between 2011 and 2014, at two HIV specialist clinics in Penang General Hospital and Seberang Jaya Hospital. We evaluated the outcome of IPT in terms of completion rate, adverse events and incidence of active TB. A total of 193 (81.1%) patients completed 6 months of IPT. Patients receiving concurrent highly active antiretroviral therapy (HAART) had significantly higher IPT completion rate (86.1%) compared to those who were not on HAART (67.7%). Major reasons for non-completion were adverse events (21/45) and defaulting from follow-up (17/45). Forty patients (18%) develop.. View More»
