Loto OM
Nigeria
Research Article
Comparison of Intramuscular Magnesium Sulphate with Low Dose Intravenous Regimen in the Management of Eclampsia in Low Resource Setting: A Randomised Study
Author(s): Idowu A, Adekanle DA, Loto OM, Ajenifuja KO, Badejoko OO, Tijani Am and Mustapha AOIdowu A, Adekanle DA, Loto OM, Ajenifuja KO, Badejoko OO, Tijani Am and Mustapha AO
Background: Eclampsia is a major cause of maternal and perinatal morbidity and mortality. Magnesium sulphate is currently the gold standard in the management of eclamptic fit. As a result of its toxicity, current efforts are being geared towards discovering a lower dosage without compromising its efficacy.
Objective: To compare the effectiveness of low-dose magnesium sulphate and standard Pritchard regimen in controlling eclamptic fit and preventing adverse maternal and neonatal outcomes in eclamptic patients
Methodology: This study was a randomized clinical trial comparing low-dose with standard Pritchard regimen. Twenty eight patients (the cases) randomized into low-dose regimen group received 4g loading dose, I.V. 4 g and a maintenance dose of 0.6 g/hr through intravenous infusion for a period of 24 hours post-d.. View More»
