Journal of Multiple Sclerosis
ISSN - 2376-0389NLM - 101654564
Ludolph AC
Germany
Research Article
Immunoadsorption with Regenerating Columns in Treatment of Steroid-Refractory Relapse in Multiple Sclerosis and Optic Neuritis
Author(s): Dorst J, Kunz M, Vintonyak O, Senel M, Rau D, Fathinia P, Hansel A, Endruhn S, Fangerau T, Taranu D, Gastl R, Jesse S, Schuster J, Ludolph AC and Tumani HDorst J, Kunz M, Vintonyak O, Senel M, Rau D, Fathinia P, Hansel A, Endruhn S, Fangerau T, Taranu D, Gastl R, Jesse S, Schuster J, Ludolph AC and Tumani H
Objective: Immunoadsorption (IA) is increasingly recognized as a promising and low-risk therapy option in a variety of autoimmune neurologic disorders. Along with plasma exchange (PE) it is considered as a second line therapy in multiple sclerosis (MS) and optic neuritis (ON) and usually regarded as a therapy option in case of steroidrefractory relapse in most guidelines. However, systematic prospective data is missing, especially regarding modern efficient adsorber systems with regenerating columns. The aim of this study was to provide efficacy and tolerability data in patients with steroid-refractory multiple sclerosis and optic neuritis.
Methods: We prospectively investigated the clinical course of 25 patients with steroid-refractory relapse of MS or ON who were treated with IA using regenerating protein A columns. IA was performed on 5 c.. View More»
