Malgorzata Szczesna
Poland
Research Article
Photoperiod Influences the Effects of Ghrelin and Serotonin Receptor Agonist on
Growth Hormone and Prolactin Secretion in Sheep
Author(s): Dorota A Zieba, Katarzyna Kirsz, Malgorzata Szczesna, Edyta Molik, Katarzyna Romanowicz and Tomasz MisztalDorota A Zieba, Katarzyna Kirsz, Malgorzata Szczesna, Edyta Molik, Katarzyna Romanowicz and Tomasz Misztal
Objective: Recent studies have identified a novel heterodimer involving the ghrelin receptor (GHS-R1A) and the
5-HT2C receptor, a subtype of serotonin receptors. Whether or not interactions between GHS-R1A and the 5-HT2C
receptor exist and how they are modulated by photoperiod and nutritional status in seasonally animals remains
unknown. The aims of this study were to determine the effects of ghrelin and a 5-HT2B/2C serotonin receptor
agonist, 1-(3-chlorophenyl) piperazine hydrochloride (m-CPP), on GH and PRL secretion under the influence of
nutritional status and photoperiod.
Methods: Normally fed (n=12) or fasted (n=12) ewes were assigned to one of 4 groups and treatments: 1) control
(saline); 2) ghrelin (2.5 μg/kg); 3) m-CPP (2.5 mg/kg); 4) ghrelin followed by m-CPP were infused once at the
beginning of the study for groups.. View More»
