Research Article
Treatment of Refractory Endometriosis-Related Pain with Vaginal Gestrinone in Pentravan Associated with Pinus Pinaster Extract and Resveratrol: A Preliminary Study
Author(s): Hugo Maia Jr, Clarice Haddad, Maria Cristina de Moura Hirsch, Wilson S D dos Santos Junior and Julio CasoyHugo Maia Jr, Clarice Haddad, Maria Cristina de Moura Hirsch, Wilson S D dos Santos Junior and Julio Casoy
Introduction: Sexual dysfunction is common in patients with endometriosis and in the majority of cases the cause of sexual dysfunction is pain. The aim of this study was to investigate the effect of a combination of vaginal gestrinone with oral pinus pinaster extract and resveratrol on the pain scores of patients with deep endometriosis refractory to previous hormone treatment.
Methods: Fifteen patients were treated with a combination of 5 mg of vaginal gestrinone in Pentravan® (Fagron, the Netherlands) three times a week and 100 mg of oral pinus pinaster extract (Fagron, the Netherlands) together with 30 mg of resveratrol (Fagron, the Netherlands) daily.
Results: Mean pain score was 9 prior to treatment, reducing significantly to 3 (p=0.03) and 0.5 (p=0.004) after 1 and 2 months of treatment, respectively. Aft.. View More»
