Masanobu Gunji
Japan
Case Report
Lipid-rich Glomerular Capillary Thrombi, of a Patient with Waldenstrom’s Macroglobulinemia
Author(s): Masanobu Gunji, Itaru Ebihara, Megumi Koda, Yuki Okubo, Chihiro Sato, Joichi Usui, Kunihiro Yamagata, Masaki Kobayashi and Takao SaitoMasanobu Gunji, Itaru Ebihara, Megumi Koda, Yuki Okubo, Chihiro Sato, Joichi Usui, Kunihiro Yamagata, Masaki Kobayashi and Takao Saito
A 77-year-old woman was diagnosed nephrotic syndrome with Waldenström?s macroglobulinemia (WM). Renal biopsy revealed MPGN-like lesions with extensive glomerular capillary thrombi which were positive for anti-IgM and anti-lambda-light chain immunofluorescence. The electron microscopy showed characteristic thrombi intra glomerular capillary walls which were occupied with a lot of vacuoles. These structures were similar with them of lipoprotein glomerulopathy. The patient was started to treat with R-CHOP, and then nephrotic syndrome and her renal insufficiency were completely recovered. There were no previous reports of nephrotic syndrome and acute renal failure caused by oil-rich intracapillary thrombi in WM in the literature... View More»
