Journal of Multiple Sclerosis
ISSN - 2376-0389NLM - 101654564
Matilde Inglese
Tanzania
Research Article
Examination of Functional Reorganization in Multiple Sclerosis using fMRI-Guided Magnetic Resonance Spectroscopy: A Pilot Study
Author(s): Helen M Genova, Ekaterina Dobryakova, Oded Gonen, Frank Hillary, Glenn Wylie, William E. Wu, Matilde Inglese, Nancy Chiaravalloti and John DeLucaHelen M Genova, Ekaterina Dobryakova, Oded Gonen, Frank Hillary, Glenn Wylie, William E. Wu, Matilde Inglese, Nancy Chiaravalloti and John DeLuca
Introduction: Compared to healthy controls (HCs), individuals with multiple sclerosis (MS) show aberrant brain activation patterns during performance of certain tasks. Such patterns of activity have been interpreted as restructuring of functional connections, i.e. the brain’s ability to change neural networks in response to pathology. However, the relationship between neural damage related to MS and abnormal brain activation is not well understood. Here, we utilized proton magnetic resonance spectroscopy 1H-MRS, a technique sensitive to underlying pathological substrates, to examine neurometabolite levels in the brain of MS individuals in conjunction with fMRI in order to better understand the relationship between neuropathology and brain activity in MS.
Methods: Neurometabolite levels in pre-selected regions were correlated with brain a.. View More»
DOI: 10.4172/jmso.1000120
