Maurizio Fava
Tanzania
Research Article
Symptoms of Anxiety and Irritability in Patients with Major Depressive Disorder
Author(s): T. Michelle Brown, Dana B. DiBenedetti, Natalya Danchenko, Emmanuelle Weiller and Maurizio FavaT. Michelle Brown, Dana B. DiBenedetti, Natalya Danchenko, Emmanuelle Weiller and Maurizio Fava
Background: Anxiety and irritability often coexist in patients with major depressive disorder (MDD). The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) added criteria for an anxious distress specifier for MDD. This study aimed at understanding the various components of anxiety and irritability, their impact, and relationships among them in MDD; and the association of anxious distress and irritability with treatment response.
Methods: Focus groups were conducted with patients with MDD reporting symptoms of anxiety, irritability, agitation, and/or aggression. Clinical study data were pooled from open-label antidepressant treatment (ADT) phases of seven studies in patients with MDD and a history of inadequate response for the current depressive episode to one to three ADTs (N = 5,182). Post hoc criteria using study.. View More»
