Department of Pediatrics and Physiology & Pharmacology, Schulich School of Medicine & Dentistry,University of Western Ontario, London, Ontario, Canada
Biography
My research interests involve mechanistic studies of serious adverse drug reactions with a specific focus on drug hypersensitivity. Our group is working on determining the relative contributions of metabolism and immune response in the development of drug hypersensitivity to a number of drugs including commonly used antibiotics, anti-epilepsy drugs and chemotherapeutic agents. More recently we are investigating how genetically determined variations in drug metabolism, immune response, drug transport and cellular repair determine risk for serious adverse events to chemotherapy for childhood cancer.
