Minyahil Alebachew Woldu
School of Pharmacy,
P.O. Box: 9086, Addis Ababa
Ethiopia
Research Article
The Risk of Hepatotoxicity Associated with HAART/Anti-Tb Co-Treatment: A Case Control Study in a Central Ethiopian Referral Hospital
Author(s): Minyahil Alebachew Woldu, Henok Demeke Getaneh, Jimma Likisa Lenjisa, Gobezie Temesgen Tegegn, Gurmu Tesafye Umeta and Hunduma Dinsa AyanoMinyahil Alebachew Woldu, Henok Demeke Getaneh, Jimma Likisa Lenjisa, Gobezie Temesgen Tegegn, Gurmu Tesafye Umeta and Hunduma Dinsa Ayano
Background: Hepatotoxicity is historically the 3rd most common reason for ART toxicity related discontinuation. Liver toxicity leads to medical visit, work plan exams, and frequent hospital admissions all of which increases expenses. The objective of this study was to determine the risk of hepatotoxicity and identify the major predictors that may cause hepatotoxicity in the study place.
Methods: A case-control study was done by reviewing a total of 105 TB/HIV co- infected patients' charts.
Results: Of the total 105 patients included in the study, 21 (20%) developed hepatotoxicity. Fifty four (51.43%) of the participants were females. The mean CD4 count of the patients was 205.1 + 96.18 cells/μL and ranged from the lowest count of 51cells/μl to the highest recorded count of 559cells/μl. The most frequen.. View More»
