Nuray Bilge
Turkey
Research Article
ABCB1 C3435T Gene Polymorphism Frequency and Correlation with Clinical Parameters in Multiple Sclerosis
Author(s): Eda Balkan and Nuray BilgeEda Balkan and Nuray Bilge
Background: People with Multiple Sclerosis (MS) show varying responses to the same drugs, suggesting a genetic factor. In addition, certain ABCB1 gene polymorphisms have been associated with resistance to many drugs. In the era of individualized treatment, identifying possible genetic causes of drug non responsiveness in MS patients may enable the prediction of nonresponse before treatment. Research is needed to determine relationships between ABCB1 polymorphisms and patients’ clinical parameters and drug response in MS.
Objective: This study investigated the presence of ABCB1 C3435T polymorphism among patients with MS and evaluated possible associations between C3435T variants and disease activity and clinical parameters in MS.
Materials and Methods: The study included 100 patients.. View More»
