Oseni Bashiru Anthony
Nigeria
Research Article
Haematologic Response in Hyperglycaemic Rats Experimentally Induced with Alloxan
Author(s): Fakoya Olugbenga Olatunde and Oseni Bashiru AnthonyFakoya Olugbenga Olatunde and Oseni Bashiru Anthony
Background: Severe hyperglycaemia has been associated with metabolic and organ dysfunctions with insufficient information on haematologic abnormalities. This study investigates the effect of induced hyperglycaemia on some peripheral blood and bone marrow indices with a view to mimic haematologic picture of poorly and untreated diabetes mellitus patients.
Methods: Sixty male albino rats weighing 175-250 g used for this study were divided equally into control and test groups. Hyperglycaemia was induced with 170 kg bwt-1 alloxan intraperitonaely in the test group while control groups received sterile normal saline. At day 12 post induction haematological parameters were investigated as packed cell volume, white blood cell count (total and differential), haemoglobin concentration, red cell count, red cell indices of mean cell volume, mean cell haem.. View More»
