Osim EE
Nigeria
Research Article
Morphology of the Small Intestine of Albino Wistar Rats Following Long Term Administration of Nevirapine
Author(s): Umoren EB and Osim EEUmoren EB and Osim EE
Background: Nevirapine (NVP) is an antiretroviral medication that prevents human immunodeficiency virus (HIV) cells from multiplying in the blood. This study was undertaken to ascertain whether NVP administration affects intestinal morphology using albino Wistar rats.
Materials and methods: Sixty adult albino Wistar rats were used for the study. Rats in the control group (n=30) were fed normal rodent chow, while the NVP group (n=30) were fed by gavage NVP (0.4 mg/kg body weight) twice daily (7:00 am and 6:00 pm) in addition to normal rodent chow for 12 weeks. All animals were allowed free access to clean drinking water. Morphological examination of tissues (duodenum, jejunum and ileum) was done.
Results: Gross morphology of the duodenum in the NVP-treated group showed hypertrophy of the Bruner’s glands within the s.. View More»
