Ospelnikova TP
Federal Research Center of Epidemiology and Microbiology, Russian Ministry of Health,
Moscow
Serbia
Research Article
Respiratory Viruses and Proinflammatory Cytokines Imbalance in Adults and Children with Bronchial Asthma
Author(s): Ospelnikova TP, Morozova OV, Isaeva EI, Andreeva SA, Lyzogub NV, Kolodyaznaya LV, Vetrova EN, Smirnova MYu, Osipova GL, Ershov FI and Chuchalin AGOspelnikova TP, Morozova OV, Isaeva EI, Andreeva SA, Lyzogub NV, Kolodyaznaya LV, Vetrova EN, Smirnova MYu, Osipova GL, Ershov FI and Chuchalin AG
Complications of acute respiratory viral infections include pneumonia, development and exacerbations of bronchial asthma (BA). Respiratory infections with human rhinoviruses, respiratory syncytial virus, adenovirus, influenza viruses A and B, parainfluenza virus’s type 1 and 3 were detected in 36.2 ± 7.1 % of clinical samples of adult patients and in 54.5 ± 10.9% of samples from children with BA using RT-PCR. High frequencies of mixed respiratory infections (35.7 ± 13.3 in adult patients and 16.7 ± 11.2 among children) along with detection of antibodies against respiratory viruses in blood sera suggested immunodeficits.
Disbalance of the IFN gene expression in the absence of IFNβ gene expression, IFNα RNA detection in 58.3% samples and IFNλ RNA - in 42.9% samples together with low levels of the IFN-stimulated antiviral prot.. View More»
