Parwez Ahmad
National Medical College Birgunj,
Nepal
Research Article
Ameliorative Potential of Euphorbia hirta (Linn.) Extract against Lipopolysaccharide Induced-neuroinflammation and Oxidative Damage in Rats
Author(s): Parwez Ahmad, Manoranjan Adak, Arshad Hussain, Shadma Wahab, Smita Singh, Chandan Mishra and Ragni SinhaParwez Ahmad, Manoranjan Adak, Arshad Hussain, Shadma Wahab, Smita Singh, Chandan Mishra and Ragni Sinha
Objective: To find out the antioxidant and anti-neuroinflammatory capabilities of Euphorbia hirta Linn. methanol extract in LPS-induced to oxidative stress animal model.
Methods: Lipopolysaccharide (LPS) was used to induce oxidative stress in rats. Oxidative stress bio-markers (TBARS, GSH, CAT and SOD) were evaluated. Enzyme-linked immunosorbent assay (ELISA) and Griess assay were used analysis of cytokines (TNF-α, IL-6 and IL-1β) and nitric oxide (NO) level in brain tissues respectively. An anxiety was calculated by elevated plus maze test. Result: LPS treated rats showed markedly depleted brain reduced glutathione (GSH) level (56.25%), superoxide dismutase (SOD) level (43.93%) and catalase (CAT) level (58.55%) in brain tissue, whereas a significant (p<0.01) raise in malondialdehyde (MDA) level (106.67%), nitric .. View More»
