Review Article
Increasing the Potential Targets and Molecularly Targeted Agent Combinations Against Cancer Cell Proliferation
Author(s): Victor M Valdespino, Victor E Valdespino-Castillo and Patricia M Valdespino-CastilloVictor M Valdespino, Victor E Valdespino-Castillo and Patricia M Valdespino-Castillo
At least four main groups of intracellular signaling pathways or submodules concur in the cell division and proliferation module: those for the control of the cell cycle, those for the metabolism programming, those for cytoskeleton remodeling, and those for DNA replication and repair. Precise signaling pathways that control cell proliferation module require the joint functional collaboration of signaling pathways of cell growth, cell survival, cell differentiation, intracellular senescence and death programs, and appropriate interaction with angiogenesis, cell micro-environment regulation and immunologic system modules. Seeking out actionable aberrations in cancer cells may now selectively targeted by drug compounds to optimize treatment efficacy and minimize toxicity.
This critical review provides an overview of the use of the CDK4/6 inhibitors as the first cell cycle inhib.. View More»
