Paul A. Lapchak
Cedars-Sinai Medical Center, Department of Neurology,
Davis Research Building, D- 2091, 110 N, George Burns Road, Los Angeles, CA 90048
Tanzania
Editorial
Vascular Dysfunction in Brain Hemorrhage: Translational Pathways to Developing New Treatments from Old Targets
Author(s): Paul A. Lapchak and Qiang WuPaul A. Lapchak and Qiang Wu
Hemorrhagic stroke which is a form of stroke that affects 20% of all stroke patients is a devastating condition for which new treatments must be developed. Current treatment methods are quite insufficient to reduce long term morbidity and high mortality rate, up to 50%, associated with bleeding into critical brain structures, into ventricular spaces and within the subarachnoid space. During the last 10-15 years, significant advances in the understanding of important mechanisms that contribute to cell death and clinical deficits have been made. The most important observations revolve around a key set of basic mechanisms that are altered in brain bleeding models, a hemorrhage cascade, including activation of membrane metalloproteinases, oxidative stress and both inflammatory and coagulation pathways. Moreover, it is now becoming apparent that brain hemorrhage can activate the ischemic c.. View More»
