Pinchuk GV
Tanzania
Review Article
All is Not Butter that Comes from the Cow: The Bovine Viral Diarrhea. Understanding the Pathogenesis of Cytopathic and Non-Cytopathic Infection
Author(s): Pinchuk LM, Ammari MG and Pinchuk GVPinchuk LM, Ammari MG and Pinchuk GV
Bovine viral diarrhea infections are seen in all ages and breeds of cattle worldwide and have significant economic impact due to the productive and reproductive losses. The infectious agents that cause this disease, Bovine viral diarrhea viruses (BVDVs) may occur as two biotypes, of which one is non-cytopathic (ncp) and the other cytopathic (cp), classified according to whether or not they produce visible changes in cell culture. Cytopathic biotypes of BVDV can be created through internal deletion or recombination of RNA of ncp biotypes. The mechanisms of this change are not sufficiently understood. In this review, we discuss the work that has been done to date in our laboratory using methods of proteomics, cellular and molecular biology, and immunology. We found that both biotypes cause numerous changes in the expression levels of the proteins in monocytes, including proteins related.. View More»
