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Journal of Molecular Imaging & Dynamics

ISSN - 2155-9937

Pratip Bhattacharya

Pratip Bhattacharya

Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, USA

Biography
The energy-yielding mitochondrial Krebs cycle has been shown in many cancers and other diseases to be inhibited or mutated. In most cells, the Krebs cycle with oxidative phosphorylation generates approximately 90% of the adenosine triphosphate in the cell. We designed and hyperpolarized carbon-13 labeled succinate (SUC) and its derivative diethyl succinate (DES) to interrogate the Krebs cycle in real-time in cancer animal models

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