Journal of Multiple Sclerosis
ISSN - 2376-0389NLM - 101654564
Prue H Hart
Telethon Kids Institute,
PO Box 855, West Perth, WA 6872
Australia
Research Article
UV Irradiation of Skin Regulates a Murine Model of Multiple Sclerosis
Author(s): Sian Geldenhuys, Mohammad G Mohammad, Hui Li, Masoud Hassanpour, Royce LX Ng, Naomi M Scott, Robyn M Lucas, David A Brown and Prue H HartSian Geldenhuys, Mohammad G Mohammad, Hui Li, Masoud Hassanpour, Royce LX Ng, Naomi M Scott, Robyn M Lucas, David A Brown and Prue H Hart
Objective: The prevalence of multiple sclerosis follows a latitude gradient, with increased disease at higher latitudes. Previous studies have focused on a vitamin D hypothesis; although recent evidence suggests that exposure to ultraviolet radiation (UVR) itself may be important. In this study, the effects of UVR on the development of experimental autoimmune encephalomyelitis (EAE) were examined.
Methods: C57BL/6 mice were irradiated with a single erythemal dose of UVR (8 kJ/m2), or 4 daily sub-erythemal doses (1 kJ/m2), before sensitisation to myelin oligodendrocyte glycoprotein peptide. The UV irradiation protocols used do not increase 25-hydroxyvitamin D concentrations in serum of vitamin D-sufficient mice. The onset of EAE was recorded and mice were clinically monitored for 40 days.
Results:.. View More»
