Rajendra B Nerli
India
Review Article
Single Nucleotide Polymorphisms: A New Paradigm in Predicting the Risk of Prostate Cancer
Author(s): Shridhar Ghagane, Rajendra B Nerli, Basappa Basawanneppa Kaliwal and Murigendra B HiremathShridhar Ghagane, Rajendra B Nerli, Basappa Basawanneppa Kaliwal and Murigendra B Hiremath
Prostate cancer (PC) is a most important health care problem because of its high prevalence, health-related costs, and mortality. Even though most patients have clinically localized and indolent tumors at diagnosis, worldwide, this disease still holds second place in the leading causes of cancer deaths. Research on susceptibility genes is one of hot issues in risk factors of prostate cancer. Nevertheless, the confirmation of prostate cancer susceptibility genes has been challenging. Thus focusing on the increasing number of single nucleotide polymorphisms (SNPs) that have been suggested to be implicated in the development and progression of PC. While individual SNPs are only moderately associated with PC risk, in combination, they have a stronger association. Therefore, identification of numerous variations in genes and analysis of their effects may lead to a better understanding of t.. View More»
