Ramin Lotfi
Head of the Department for Innovative Cellular Therapeutics, Institute of Transfusion Medicine, University Hospital Ulm,
Helmholtzstraße 10, 89081 Ulm
Germany
Research Article
Necrosis-Associated Factors (DAMPs) Including S100A4 Used to Pulse Dendritic Cells (DCs) Induce Regulatory T cells
Author(s): Ramin Lotfi, Denis Sebastian Wiegmann, Lisa Asseck, Alexander Erle, Tatjana Yildiz, Bernd Jahrsdörfer and Hubert SchrezenmeierRamin Lotfi, Denis Sebastian Wiegmann, Lisa Asseck, Alexander Erle, Tatjana Yildiz, Bernd Jahrsdörfer and Hubert Schrezenmeier
Emerging data support the immunosuppressive nature of the tumour microenvironment, which interferes with the efficacy of Dendritic Cells (DCs) used in cancer vaccination not only by rendering these immune cells unable to induce specific immune responses, but also by turning them into promoters of tumour growth.
A characteristic feature within the tumour microenvironment of advanced solid tumours is the necrotic cell death with subsequent release of necrosis-/Damage-Associated Molecular Patterns (DAMPs). DAMPs are known to induce tissue healing processes including angiogenesis and immune suppression, thus necrotic tumours harness the regenerative capacities of the host for their own survival and proliferation.
We examined the impact of DAMPs including S100A4 on DC-induced T cell proliferation. Human monocyte
derived DCs were pulsed with DAM.. View More»
