Rasha I Noreldin
Egypt
Research Article
Serum Osteopontin and Cytokeratin-18 in Chronic Hepatitis C Patients
Author(s): Gehan K El-Saeed, Gamal Y Aboraia, Rasha I Noreldin and Ayman A AlghoraiebGehan K El-Saeed, Gamal Y Aboraia, Rasha I Noreldin and Ayman A Alghoraieb
Chronic hepatitis C is a global health problem; most patients are at risk for developing fibrosis and cirrhosis. Histological examination of liver biopsies is currently the gold standard for the detection of early liver damage, but there is a strong need for better noninvasive methods. The aim of this study was to evaluate the association between serum osteopontin (OPN) level, serum cytokeratin 18 M30 (CK-18 M30) neoepitope level and the histological severity of hepatic fibrosis in hepatitis C virus (HCV) induced patients. Subjects and methods: This study included 89 subjects, 70 with chronic hepatitis C virus infection, they were classified into 2 groups according to METAVIR fibrosis stage as follows: group I (stage 2 or less was considered as mild liver fibrosis) included 50 patient, group II (stage 3 or more was considered as extensive fibrosis) included 20 patients and 19 healthy .. View More»
