René Andrade Machado
National Institute of Neurology and Neurosurgery,
Epilepsy Section
Cuba
Research Article
Electroclinical Features of Lennox-Gastaut Syndrome in Adulthood and Adolescence
Author(s): Adriana Ma Goicoechea Astencio, René Andrade Machado, Yudith Merayo, Andrés Rodrigo Solarte Mila, Martha Jiménez Jaramillo and Juan Felipe Alvarez RestrepoAdriana Ma Goicoechea Astencio, René Andrade Machado, Yudith Merayo, Andrés Rodrigo Solarte Mila, Martha Jiménez Jaramillo and Juan Felipe Alvarez Restrepo
Introduction: Lennox- Gastaut Syndrome (LGS) is characterized by seizures which may have inconspicuous semiological features so they may be unrecognized while patients are continuously deteriorating. To confirm its clinical and electrographic characteristics is mandatory, which has therapeutic and prognostic implications. Those features have not been completely elucidated in LGS in adulthood.
Purpose: We performed a descriptive study to investigate seizure types, interictal and ictal EEG characteristics and cognitive outcome in adult LGS subjects.
Methods: We evaluated 28 cases with development impairment and several refractory seizure types, which included tonic seizures, in order to make a screening of LGS. We confirm LGS diagnosis in 24 patients older than 12 years who were assessed by video-EEG, particularly to record seizure types and EEG findings as well as cogniti.. View More»
