Journal of Multiple Sclerosis
ISSN - 2376-0389NLM - 101654564
Richard Bostelmann
Germany
Research Article
Analysis of 258 Different Lesions of the Central Nervous System for Real Time Histopathological Diagnosis Using Confocal Laser Endomicroscopy
Author(s): Samira Daali, Mehreen Javed, Ann-Kristin Altekoester, Maximilian Linxweiler, Richard Bostelmann, Juergen Schlegel, Alhadi Igressa and Patra CharalampakiSamira Daali, Mehreen Javed, Ann-Kristin Altekoester, Maximilian Linxweiler, Richard Bostelmann, Juergen Schlegel, Alhadi Igressa and Patra Charalampaki
Objective: The safe removal of central nervous system tumors in or near eloquent tissue remains extremely challenging due to its complex anatomy. The injury of eloquent tissue can have serious consequences for both mental and physical health while an insufficiently resected tumor bears a high risk of tumor recurrence decreasing the patient’s life quality and quantity. The novel method, confocal laser endomicroscopy (CLE), promises safe tumor resection as it permits intraoperative histological imaging of tissues in real-time. Thus, aim of the current study was to evaluate CLE for a fast diagnosis of brain and spinal cord lesions in neurosurgery.
Methods: CLE was used for an ex vivo assessment of tumor samples from 258 diverse central nervous system lesions. Additionally, traditional histology was performed on the same examined tissue as.. View More»
