Robert A Kloner
Tanzania
Research Article
Effect of Diabetes on Myocardial Infarct and No Reflow Size in an Experimental Rat Model and Clinical Trial
Author(s): Wangde Dai, Robert A Kloner, Jianru Shi, Juan Carreno, Serge Korjian, Yazan Daaboul, Michael C Gibson, Muriel Bouly and Marc IsabelleWangde Dai, Robert A Kloner, Jianru Shi, Juan Carreno, Serge Korjian, Yazan Daaboul, Michael C Gibson, Muriel Bouly and Marc Isabelle
Background: We determined the effect of diabetes on no reflow and myocardial infarct sizes in both an experimental rat model of diabetes and a contemporary trial of subjects with STEMI.
Methods: Adult Zucker Diabetic Fatty (ZDF) and Sprague Dawley (SD) rats (n=15 each group) were subjected to left coronary artery occlusion for 30 min followed by 3 h of reperfusion. In the clinical trial, the myocardial infarct (MI) size and the zone of microvascular obstruction were assessed in 258 non-diabetic MI patient and 34 diabetic MI patients.
Results: There was no difference in infarct size (median) in ZDF rats (49.9%) versus SD rats (59.6%; p=0.32); there was no difference in no-reflow size (mean ± SEM) in ZDF rats (32.5 ± 3.5%) versus SD rats (32.7 ± 4.3%; p=0.97). In the clinical study, CK-MB and Tro.. View More»
