Roberto Perricone
Italy
Research Article
A Prospective Study on Inflammatory Cytokines and Bone Metabolism Mediators in Patients Affected by Rheumatoid and Psoriatic Arthritis treated with Adalimumab
Author(s): Maria Sole Chimenti, Paola Conigliaro, Maria Morello, Rossella Zenobi, Paola Triggianese, Carlo Perricone, Lucia Novelli, Sergio Bernardini and Roberto PerriconeMaria Sole Chimenti, Paola Conigliaro, Maria Morello, Rossella Zenobi, Paola Triggianese, Carlo Perricone, Lucia Novelli, Sergio Bernardini and Roberto Perricone
Rheumatoid (RA) and Psoriatic arthritis (PsA) are characterized by extensive synovitis resulting in bone destruction in both diseases and new bone formation in PsA. Objective: This prospective study analyzed interleukin (IL)-6, IL-17, IL-23, tumor necrosis factor (TNF)-α serum and synovial fluid (SF) levels and osteoprotegerin (OPG), bone-specific alkaline phosphatase (BAP) and D-vitamin (D-Vit) serum levels in RA and PsA patients before and after anti-TNF-α. Methods: 15 RA and 15 PsA patients with knee effusion and starting adalimumab (ADA) treatment were enrolled. Serum and SF from inflamed knee joint samples were obtained at baseline and after 24 weeks of treatment. Statistical analysis was performed using Graph Pad 5.0 statistical software. Results: In RA and PsA, SF IL-6, IL-17, and TNF-α were higher than serum levels while higher serum IL-23 was detected than i.. View More»
