Saeed El- Ashram
China
Research Article
Synthesis of Sialyl Lewis X Related Tetrasaccharide Library Through Random Fucosylation on a Partially Protected Trisaccharide
Author(s): Yili Ding, Chamakura VNS Varaprasad, Saeed El- Ashram, Jiedan Liao, Nan Zhang and Bingyun WangYili Ding, Chamakura VNS Varaprasad, Saeed El- Ashram, Jiedan Liao, Nan Zhang and Bingyun Wang
Background
Carbohydrate recognition has been shown to be involved in various biological processes. E-selectin is expressed on the endothelial cells stimulated by cytokines, such as IL-1β or TNF-α at inflammatory sites and plays an important role in the transport of neutrophils to inflammatory sites. The tetrasaccharide SLex is distributed on the surface of neutrophils and has been shown to be a ligand recognized by E-selectin. SLex and its derivatives can block the interaction between SLex and E-selectin and will be useful as the anti-inflammatory and anti-tumor agents.
Results
Random fucosylation on a partially protected sialyl LacNAc trisaccharide, resulted in the corresponding glycosylated products as a mixture. After careful purification, debenzylation, deacetylation, alkaline hydrolysis and further purific.. View More»
