Research Article
Association of Helicobacter Pylori Infection with Oxidative DNA Damage and Atherosclerosis in Rheumatoid Arthritis Patients
Author(s): Doaa Waseem Nada, Amal Mohamad El-Barbary, Sally Abd El monem El Nawasany, Rasha Ahmed Gaber, Radwa Mahmoud El-sharaby, Muhammad Tarek Abdel Ghafar and Hossam Abdelhafiz ZaytounDoaa Waseem Nada, Amal Mohamad El-Barbary, Sally Abd El monem El Nawasany, Rasha Ahmed Gaber, Radwa Mahmoud El-sharaby, Muhammad Tarek Abdel Ghafar and Hossam Abdelhafiz Zaytoun
Objectives: to evaluate the associations between Helicobacter pylori (HP) with oxidative DNA damage and subclinical atherosclerosis in rheumatoid arthritis (RA) patients.
Methods: Eighty RA patients were divided into two groups according to the presence of anti-HP antibodies. In addition, to forty healthy volunteers. All patients were subjected to DAS-28, ESR , hsCRP ,RF, Anti-CCP, Lipid profiles, serum anti-HP antibodies, 8-hydroxydeoxyguanosine, Oxidized LDL, IL-6,carotid intima media thickness (cIMT) and flow mediated dilatation of the brachial artery (FMD).
Results: HP positive RA patients revealed significantly higher disease activity, RF, Anti-CCP, dyslipidemia, 8- OHdG, ox-LDL, cIMT and lower FMD% compared to HP negative patients. There was positive correlation between anti-HP antibodies with disease activity pa.. View More»
