Sarah J Felton
Dermatology Centre, Salford Royal NHS Foundation Trust, Stott Lane, Manchester, M6 8HD,
United Kingdom
Case Report
Cutaneous Erosions: An Under-Recognised and Rare Side Effect of Methotrexate Treatment, in the Absence of Systemic Methotrexate Toxicity
Author(s): Sarah J Felton, Firas Al-Niaimi and Janice E FergusonSarah J Felton, Firas Al-Niaimi and Janice E Ferguson
Methotrexate is a potentially toxic anti-folate drug widely used in the treatment of skin disease. We describe here a case of cutaneous erosions occurring in previously erythrodermic skin after only four weeks of very low-dose therapy, in the absence of features of systemic methotrexate toxicity. We thus report that localised cutaneous toxicity can occur in isolation, and propose that cutaneous erosions be considered a rare but potentially serious side effect of methotrexate, rather than a sign of actual or impending systemic toxicity. .. View More»
