Satoshi Goto
Department of Neurodegenerative Disorders Research, Institute of Biomedical Sciences, Graduate School of Medical Sciences, Tokushima University, Tokushima 770-8503,
Japan
Commentary
A Short Commentary on Globus Pallidus Internus Deep Brain Stimulation in
Primary Meige Syndrome
Author(s): Ryoma Morigaki and Satoshi GotoRyoma Morigaki and Satoshi Goto
Meige syndrome is a type of segmental dystonia that manifests a combination of blepharospasm and oromandibular dystonia and is often associated with other types of craniocervical dystonia. Although the precise pathogenesis of primary Meige syndrome remains to be elucidated, it has been suggested that this movement disorder might be a basal ganglia disorder. Multiple single case reports and open-labelled small case series have shown that globus pallidus internus deep brain stimulation (GPi-DBS) could result in therapeutic benefits in patients with severe Meige syndrome. However, randomized and controlled trials are necessary to accurately assess the safety and therapeutic efficacy of GPi-DBS in treating patients with Meige syndrome. This short commentary introduces the current use of GPi-DBS in the treatment of medically refractory Meige syndrome... View More»
